Incidence of influenza A(H3N2) virus infections in Hong Kong in a longitudinal sero-epidemiological study, 2009-2015
Identifieur interne : 000520 ( Main/Exploration ); précédent : 000519; suivant : 000521Incidence of influenza A(H3N2) virus infections in Hong Kong in a longitudinal sero-epidemiological study, 2009-2015
Auteurs : Vivian W. I. Wei [République populaire de Chine] ; Jessica Y. T. Wong [République populaire de Chine] ; Ranawaka A. P. M. Perera [République populaire de Chine] ; Kin On Kwok [République populaire de Chine] ; Vicky J. Fang [République populaire de Chine] ; Ian G. Barr [Australie] ; J. S. Malik Peiris [République populaire de Chine] ; Steven Riley [Royaume-Uni] ; Benjamin J. Cowling [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2018.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Charge virale, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (histoire), Grippe humaine (virologie), Grippe humaine (épidémiologie), Histoire du 21ème siècle, Hong Kong (épidémiologie), Humains, Incidence, Jeune adulte, Mâle, Saisons, Sous-type H3N2 du virus de la grippe A (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la population, Susceptibilité à une maladie, Études de cohortes, Études séroépidémiologiques.
- MESH :
- histoire : Grippe humaine.
- immunologie : Sous-type H3N2 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine, Hong Kong.
- Adolescent, Adulte, Adulte d'âge moyen, Charge virale, Enfant, Enfant d'âge préscolaire, Femelle, Histoire du 21ème siècle, Humains, Incidence, Jeune adulte, Mâle, Saisons, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la population, Susceptibilité à une maladie, Études de cohortes, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cohort Studies, Disease Susceptibility, Female, History, 21st Century, Hong Kong (epidemiology), Humans, Incidence, Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (history), Influenza, Human (virology), Male, Middle Aged, Population Surveillance, Seasons, Seroepidemiologic Studies, Viral Load, Young Adult.
- MESH :
- epidemiology : Hong Kong, Influenza, Human.
- history : Influenza, Human.
- immunology : Influenza A Virus, H3N2 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cohort Studies, Disease Susceptibility, Female, History, 21st Century, Humans, Incidence, Male, Middle Aged, Population Surveillance, Seasons, Seroepidemiologic Studies, Viral Load, Young Adult.
Abstract
Many serologic studies were done during and after the 2009 influenza pandemic, to estimate the cumulative incidence of influenza A(H1N1)pdm09 virus infections, but there are few comparative estimates of the incidence of influenza A(H3N2) virus infections during epidemics.
We conducted a longitudinal serologic study in Hong Kong. We collected sera annually and tested samples from 2009–13 by HAI against the A/Perth/16/2009(H3N2) virus, and samples from 2013–15 against the A/Victoria/361/2011(H3N2) virus using the hemagglutination inhibition (HAI) assay. We estimated the cumulative incidence of infections based on 4-fold or greater rises in HAI titers in consecutive sera.
There were four major H3N2 epidemics: (1) Aug-Oct 2010; (2) Mar-Jun 2012; (3) Jul-Oct 2013; and (4) Jun-Jul 2014. Between 516 and 619 relevant pairs of sera were available for each epidemic. We estimated that 9%, 19%, 7% and 7% of the population were infected in each epidemic, respectively, with higher incidence in children in epidemics 1 and 4.
We found that re-infections in each of the four H3N2 epidemics that occurred from 2010 through 2014 were rare. The largest H3N2 epidemic occurred with the lowest level of pre-epidemic immunity.
Url:
DOI: 10.1371/journal.pone.0197504
PubMed: 29795587
PubMed Central: 5967746
Affiliations:
- Australie, Royaume-Uni, République populaire de Chine
- Angleterre, Grand Londres, Guangdong, Victoria (État)
- Londres, Melbourne, Sha Tin, Shenzhen
- Université chinoise de Hong Kong, Université de Melbourne
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Le document en format XML
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I." last="Wei">Vivian W. I. Wei</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Wong, Jessica Y T" sort="Wong, Jessica Y T" uniqKey="Wong J" first="Jessica Y. T." last="Wong">Jessica Y. T. Wong</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A. P. M." last="Perera">Ranawaka A. P. M. Perera</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre of Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Kwok, Kin On" sort="Kwok, Kin On" uniqKey="Kwok K" first="Kin On" last="Kwok">Kin On Kwok</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Shenzhen Research Institute of the Chinese University of Hong Kong, Shenzhen, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen Research Institute of the Chinese University of Hong Kong, Shenzhen</wicri:regionArea><placeName><settlement type="city">Shenzhen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Fang, Vicky J" sort="Fang, Vicky J" uniqKey="Fang V" first="Vicky J." last="Fang">Vicky J. Fang</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>WHO Collaborating Centre for Reference and Research, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>WHO Collaborating Centre for Reference and Research, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff007"><addr-line>Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre of Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Riley, Steven" sort="Riley, Steven" uniqKey="Riley S" first="Steven" last="Riley">Steven Riley</name><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>MRC Centre for Outbreak Analysis and Modelling, Department for Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Outbreak Analysis and Modelling, Department for Infectious Disease Epidemiology, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cowling, Benjamin J" sort="Cowling, Benjamin J" uniqKey="Cowling B" first="Benjamin J." last="Cowling">Benjamin J. Cowling</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Cohort Studies</term><term>Disease Susceptibility</term><term>Female</term><term>History, 21st Century</term><term>Hong Kong (epidemiology)</term><term>Humans</term><term>Incidence</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (history)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Middle Aged</term><term>Population Surveillance</term><term>Seasons</term><term>Seroepidemiologic Studies</term><term>Viral Load</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine (histoire)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Histoire du 21ème siècle</term><term>Hong Kong (épidémiologie)</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Mâle</term><term>Saisons</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surveillance de la population</term><term>Susceptibilité à une maladie</term><term>Études de cohortes</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hong Kong</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Hong Kong</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Cohort Studies</term><term>Disease Susceptibility</term><term>Female</term><term>History, 21st Century</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Population Surveillance</term><term>Seasons</term><term>Seroepidemiologic Studies</term><term>Viral Load</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Histoire du 21ème siècle</term><term>Humains</term><term>Incidence</term><term>Jeune adulte</term><term>Mâle</term><term>Saisons</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surveillance de la population</term><term>Susceptibilité à une maladie</term><term>Études de cohortes</term><term>Études séroépidémiologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Many serologic studies were done during and after the 2009 influenza pandemic, to estimate the cumulative incidence of influenza A(H1N1)pdm09 virus infections, but there are few comparative estimates of the incidence of influenza A(H3N2) virus infections during epidemics.</p></sec><sec id="sec002"><title>Methods</title><p>We conducted a longitudinal serologic study in Hong Kong. We collected sera annually and tested samples from 2009–13 by HAI against the A/Perth/16/2009(H3N2) virus, and samples from 2013–15 against the A/Victoria/361/2011(H3N2) virus using the hemagglutination inhibition (HAI) assay. We estimated the cumulative incidence of infections based on 4-fold or greater rises in HAI titers in consecutive sera.</p></sec><sec id="sec003"><title>Results</title><p>There were four major H3N2 epidemics: (1) Aug-Oct 2010; (2) Mar-Jun 2012; (3) Jul-Oct 2013; and (4) Jun-Jul 2014. Between 516 and 619 relevant pairs of sera were available for each epidemic. We estimated that 9%, 19%, 7% and 7% of the population were infected in each epidemic, respectively, with higher incidence in children in epidemics 1 and 4.</p></sec><sec id="sec004"><title>Conclusions</title><p>We found that re-infections in each of the four H3N2 epidemics that occurred from 2010 through 2014 were rare. 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I" uniqKey="Wei V" first="Vivian W. I." last="Wei">Vivian W. I. Wei</name></noRegion><name sortKey="Cowling, Benjamin J" sort="Cowling, Benjamin J" uniqKey="Cowling B" first="Benjamin J." last="Cowling">Benjamin J. Cowling</name><name sortKey="Fang, Vicky J" sort="Fang, Vicky J" uniqKey="Fang V" first="Vicky J." last="Fang">Vicky J. Fang</name><name sortKey="Kwok, Kin On" sort="Kwok, Kin On" uniqKey="Kwok K" first="Kin On" last="Kwok">Kin On Kwok</name><name sortKey="Kwok, Kin On" sort="Kwok, Kin On" uniqKey="Kwok K" first="Kin On" last="Kwok">Kin On Kwok</name><name sortKey="Kwok, Kin On" sort="Kwok, Kin On" uniqKey="Kwok K" first="Kin On" last="Kwok">Kin On Kwok</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A. P. M." last="Perera">Ranawaka A. P. M. Perera</name><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A. P. M." last="Perera">Ranawaka A. P. M. Perera</name><name sortKey="Wei, Vivian W I" sort="Wei, Vivian W I" uniqKey="Wei V" first="Vivian W. I." last="Wei">Vivian W. I. Wei</name><name sortKey="Wong, Jessica Y T" sort="Wong, Jessica Y T" uniqKey="Wong J" first="Jessica Y. T." last="Wong">Jessica Y. T. Wong</name></country><country name="Australie"><noRegion><name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name></noRegion><name sortKey="Barr, Ian G" sort="Barr, Ian G" uniqKey="Barr I" first="Ian G." last="Barr">Ian G. Barr</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Riley, Steven" sort="Riley, Steven" uniqKey="Riley S" first="Steven" last="Riley">Steven Riley</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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